Flucloxacillin
β-lactams are considered to be less prone to drug interactions. Flucloxacillin, however, may ⬇️ tacrolimus concentration presumably through enzyme induction
The same can occur with flucloxacillin and broad spectrum azoles (vori/posa)
link.springer.com/article/10.100…
2. Pip-tazo
Pip-tazo can inhibit renal clearance of methotrexate (MTX) and results in toxicity esp when high dose MTX is used (e.g. for hematological malignancy)
academic.oup.com/jac/article/58…
3. Ciprofloxacin
Ciprofloxacin is a moderate inhibitor of CYP1A2. The concentration of theophylline can increase 2-3 folds and results in toxicity when concomitant cipro is used.
pubmed.ncbi.nlm.nih.gov/21234553/
4. Clarithromycin
Clarithromycin is a strong inhibitor of CYP3A4 and P-glycoprotein, and can interact with many commonly used drugs (e.g. Ca channel blocker, statin, antiepileptic)
It may be potentially fatal when used with colchicine in renal failure
academic.oup.com/cid/article/41…
5. TMPSMX
TMPSMX should not be given concomitantly with inhibitors of renin-angiotensin system (ACEI/ARB) and aldosterone antagonists because of potentially fatal hyperK that can occur rapidly
Remember TMP acts like a K-sparing diuretic
6. Carbapenems
Significant reduction (up to 80%) in valproate level can occur within 24hrs of starting carbapenems
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deemagclinic
deemag and chest clinic 