Monthly Archives: November 2019

Accepted Manuscript Pre-treatment with amitriptyline causes epigenetic up-regulation of neuroprotection-associated genes and has anti-apoptotic effects in mouse neuronal cells

Nguyen Quoc Vuong Tran, An Nghia Nguyen, Kyoko Takabe, Zentaro Yamagata, Kunio Miyake  PII: DOI: Reference: To appear in: Received date: Revised date: Accepted date: S0892-0362(16)30114-3 doi: 10.1016/ NTT 6700 Neurotoxicology and Teratology 17 October 2016 9 May 2017 11 May 2017 Please cite this article as: Nguyen Quoc Vuong Tran, An Nghia Nguyen, […]

Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres?

    cells       Review Alessio Squassina 1,2, Claudia Pisanu 1,3,* and Roberta Vanni 4,* 1 2 3 4 09042 Monserrato Cagliari, Italy * Correspondence: (C.P.); (R.V.); Tel.: +39-070-675-4334 (C.P.); +39-070-675-4123 (R.V.) Received: 18 December 2018; Accepted: 12 January 2019; Published: 15 January 2019  Department […]

Hepatocellular carcinoma and antidepressants: a nationwide population-based study Oncotarget, 2017, Vol. 8, (No. 18), pp: 30464-30470  Vincent Chin-Hung Chen1,2 , Chiao-Fan Lin2,3, Yi-Hsuan Hsieh2,3, Hsin-Yi Liang2,3, Kuo-You Huang4, Wei-Che Chiu5,6,*, Yena Lee7, Roger S. McIntyre7,8 and Hsiang- Lin Chan2,3 1 Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan 2 Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan 3 […]

Is Autophagy Involved in the Diverse Effects of Antidepressants

    cells       Review Theo Rein Max Planck Institute of Psychiatry, Munich 80804, Germany;; Tel.: +49-89-30622531   Received: 15 December 2018; Accepted: 9 January 2019; Published: 12 January 2019 Abstract: Autophagy has received increased attention as a conserved process governing cellular energy and protein homeostasis […]

Therapeutic spectrum in psychiatry

Introduction and definitions The concept of therapeutic spectrum is broad and can’t be fully defined at this moment in psychopharmacology as well in general pharmacology. It refers to sometimes one or both of the following concepts . 1)  the range of beneficial clinical activities of a drug to all symptom domains of a specific diseases. […]

Whole theory

A plucky amateur dared to question a celebrated psychological finding. He wound up blowing the whole theory wide open. Narratively | • Vinnie Rotondaro Illustrations by Kevin Huizenga. It was autumn of 2011. Sitting in a dimly lit London classroom, taking notes from a teacher’s slides, Nick Brown could not believe his eyes. By training […]

Treatment Options for Carbapenem-resistant Gram- negative Bacterial Infections

Clinical Infectious Diseases SUPPLEMENT ARTICLE Treatment Options for Carbapenem-resistant Gram- negative Bacterial Infections Yohei Doi1,2 1Center for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pennsylvania; and 2Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Aichi, Japan Antimicrobial resistance has become one of the greatest threats […]

Low protein diet?

Taking low carbohydrate diet and substituting carbohydrates proteins has become a leading dogma for all those who care for their looks and health. A high-protein diet is believed to keep you fit and help you lose fat and retain lean muscle mass. In an article published in Nephrology Dialysis Transplantation, Dr Kamyar Kalantar-Zadeh, Dr Holly […]


*Please circulate this far and wide. It is a chat with Dr. Abdullahi Oluwalogbon (Heart and Utility Specialist). The transcript of the chat is given below. Useful for everyone.* QUESTIONS & ANSWERS: *Question 1:* What are the thumb rules for a layman to take care of his or her heart? *Answer:* 1. Diet – Less […]

ICD 11

 INTERNATIONAL CLASSIFICATION OF DISEASES – Mortality and Morbidity Statistics CHAPTER 06 Mental, behavioural or neurodevelopmental disorders This chapter has 161 four-character categories. Code range starts with 6A00 Mental, behavioural and neurodevelopmental disorders are syndromes characterized by clinically significant disturbance in an individual’s cognition, emotional regulation, or behaviour that reflects a dysfunction in the psychological, […]

Occupational Therapy in Psychiatry and Mental Health

                                          Occupational Therapy in Psychiatry and Mental Health FiFth Edition Edited by Rosemary Crouch […]


A TALE OF TWO HOSPITALS IN TWO COUNTRIES: HOW AN EMERGENCY REVEALED BROKEN STATE OF INDIAN HEALTHCARE BY:PRAVEEN SWAMI <a class=”gplus” href=”javascript:;” onclick=”OpenSharePopup(‘;title=A tale of two hospitals in two countries: How an emergency revealed broken state of Indian healthcare’,’google’);”><i class=”icon-google-plus”></i></a> only artical content section Eight weeks ago, I lay unconscious on a sidewalk in Paris, […]

TOP 10 MEDICAL INNOVATIONS FOR 2020, According to Cleveland Clinic

CLINICAL UPDATES : Here, in order of anticipated importance, are the Cleveland Clinic’s list of top 10 medical innovations for 2020. 1. DUAL-ACTING OSTEOPOROSIS DRUG ROMOSOZUMAB In April, the US Food and Drug Administration (FDA) approved romosozumab (Evenity, Amgen), the first drug for osteoporosis that both increases bone formation and decreases bone resorption. It is indicated for […]

Doctors choice


© Dr. Rajas Deshpande “The doctor wasn’t even replying. He didn’t answer my questions” the patient, an angry lady, told me about one of my colleagues. The patient’s husband sat besides her, expressionless. I reviewed her case in detail. She had had varying complaints for over four years, mostly severe pain at various points on […]

Shakespeare’s medicine

Why should a library that specialises in the history and culture of medicine commemorate the 400th anniversary of Shakespeare’s death? Dr Anna Maerker, who provides a Shakespeare and Medicine lecture at the Wellcome Library for acting students, kicks off our Shakespeare-inspired blog series with some good reasons ‘why?’. Students from RADA at the Shakespeare and […]

National digital health blueprint

  Thenal Health Policy 2017 outlines a robust framewr)rk for achieving Health for All through the adoption of the basic principles of accessibility, quality and affordabitity, and by leveraging the power of information and communication technologies to strengthen rhe healthcire delivery systems. The historic and landmark launch ot Ayushman Bharat Schem€, which is cperational […]

Shakespeare and Medicine

Shakespeare, Smith, and Medicine Shakespeare has long been known for his medical knowledge.  References to disease, doctors, and treatments occur in almost every play––in some, like Hamlet, Troilus, Coriolanus, Lear and Timon, to the extent that they permeate the atmosphere with morbidity.  Hamlet’s muttered remark: “Something is rotten in the State of Denmark” initiates a […]

The Prostate Gland and its effect on us , (men only).

Read it and apply, esp the part on diet. Useful for all MEN over-40: A useful article / talk on Benign Prostate Hyperplasia (BPH) or in simple terms, Enlarged Prostate. Diet is the most important part of this talk which is something within our control; and it works. FULL TEXT OF PROSTATE HEALTH AWARENESS LECTURE […]

Ayodhya judgement

REPORTABLE  IN THE SUPREME COURT OF INDIA CIVIL APPELLATE JURISDICTION Civil Appeal Nos 10866-10867 of 2010 M Siddiq (D) Thr Lrs …Appellants Mahant Suresh Das & Ors Versus WITH …Respondents Civil Appeal Nos 4768-4771/2011 WITH Civil Appeal No 2636/2011 WITH Civil Appeal No 821/2011 WITH Civil Appeal No 4739/2011 WITH Civil Appeal Nos 4905-4908/2011 […]

The End of the Bicarbonate Era? A Therapeutic Application of the Stewart Approach

Page 1 of 7 AJRCCM Articles in Press. Published on 28-October- Matthew Cove MBChB1, John A. Kellum MD2 Addresses: – 1 – 2 – Department of Medicine, National University Health System, NUHS Tower Block Level 10, 1E Kent Ridge Road, Singapore 119228, Singapore. Center for Critical Care Nephrology, Department of Critical Care Medicine, University of […]

I Swear

©️ Dr. Rajas Deshpande “Have you forgotten your oath, doctor?” asked the Hon’ble minister to Dr. Prasad. The fat elderly reporter accompanying the Hon’ble minister laughed. “We must teach these doctors a lesson” he said. Being a doctor, good language and behavior is essential. So Dr. Prasad swallowed the immediate reaction that had sprung to […]

The healing patient-physician analog relationship is in critical condition

In the history of medical care, medical records served one purpose and two masters: to record diagnosis and treatment for physicians to refer to and for patients to use to transfer care when they desired. The medical record was a simple 3 x 5 or ledger card in the 1950s. The patient paid directly for […]

Ranking Antipsychotics for Efficacy and Safety in Schizophrenia

 VIEWPOINT Christoph U. Correll, MD Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York; Department of Psychiatry and Molecular Medicine, Donald and Barbara School of Medicine at Hofstra/Northwell, Hempstead, New York; The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, New York; and Department of Child and Adolescent […]

Genome-Wide Association Studies

JAMA Guide to Statistics and Methods Xiuqing Guo, PhD; Jerome I. Rotter, MD Each individual’s genetic makeup influences the presence of, mani- festation of, and susceptibility to disease. The identification of spe- cific genetic regions that influence disease for mendelian genetic con- Clinical Review & Education    Related article page 1682 ditions, such […]

Lancet article

         Volume 61, Number 6 November-December 2019                                       EDITORIAL Recovery […]

HEALING the Doctor- Patient Strife

The book is a good effort. However , there are serious problems in the doctor- patient relationship and the way medicine is commercialised. Here are two recent stories from The Hindu- open page. The remedies have to be at multiple levels including the way medicine is practiced. Murthy The Hindu, Oct 20 2019 Recently, I […]

A guide to wellbeing for medical students

  EXAMINATIONS      STRESS   RELATIONSHIPS RAGGING MENTAL WELLBEING INDEPENDENCE SEXUALIT SELF-CARE  TIME MANAGEMENT     Disclaimer: Any technology platform, nutrition and exercise suggestions in this book should not be construed as medical advice or endorsements by White Swan Foundation. We have provided additional reading material […]


a new study appearing in the journal Science, a team led by Michigan Medicine researchers, working with collaborators at Harvard, has discovered a specific mechanism by which a “weapon” used by the immune system, called itaconate, targets Mtb. Researchers only recently discovered that itaconate is produced in large amounts by the immune system when under […]