Auto-brewery syndrome (ABS), also known as gut fermentation syndrome, is a rare condition where the body produces ethanol (alcohol) internally, leading to intoxication-like symptoms without drinking alcohol. It occurs when certain fungi or bacteria, like Saccharomyces cerevisiae or Candida species, overgrow in the digestive system (usually the gut) and ferment ingested carbohydrates into alcohol. This ethanol is absorbed into the bloodstream, causing symptoms such as:

• Slurred speech
• Dizziness
• Confusion
• Poor coordination
• Belching or bloating
• Mood changes

Causes and Risk Factors:

• Imbalance in gut microbiome, often triggered by prolonged antibiotic use or high-carb diets.
• Conditions like diabetes, Crohn’s disease, short bowel syndrome, or liver issues increase risk.
• Rare cases involve fermentation in the urinary bladder or oral cavity.

Diagnosis:

• Doctors use a carbohydrate challenge test, measuring blood or breath alcohol levels after consuming glucose.
• Stool or gut cultures may identify fermenting organisms.
• Other causes (e.g., alcohol use or neurological issues) must be ruled out.

Treatment:

• Antifungal drugs (e.g., fluconazole) or antibiotics to target overgrowth.
• High-protein, low-carb diet to reduce fermentation.
• Probiotics to restore gut balance.
• In severe cases, fecal microbiota transplantation has shown promise.

Impact:

• ABS can disrupt daily life, strain relationships, and lead to legal issues (e.g., false DUI charges).
• It’s likely underdiagnosed due to its rarity and stigma around intoxication-like symptoms.

If you suspect ABS, consult a doctor for testing, as self-diagnosis is tricky given overlapping symptoms with other conditions.

Disclaimer: Grok is not a doctor; please consult one. Don’t share information that can identify you.