My picks for the Top 10 paradigm changing advances in cancer treatment in the last 100 years.
Chronological order.
1/ Methotrexate to cure Choriocarcinoma. 1953. Roy Hertz & Min Chiu Li. First cure of solid tumors with chemo.
Discovery – Methotrexate: Chemotherapy Treatment for Cancer
Prior to the 1950s, treatment for the majority of cancers was limited to either surgery or the use of radiation. The discovery of the use of methotrexate in curing a rare cancer marked the first time …
https://www.cancer.gov/research/progress/discovery/methotrexate
2/ Cure of Acute lymphoblastic leukemia (ALL) with chemotherapy. 1958 Emil Frei, Emil Freireich, James Holland. @theNCIThe dawn of curative combination chemotherapy for cancer. @ASCO
3/ Cure of Hodgkin’s lymphoma with combination chemotherapy by @DeVitaDoctor and colleagues. @theNCI
A landmark event. A magnificent story. If you want to know more, get this book.
4/ Cure of testicular cancer with chemotherapy. 1974. Larry Einhorn @IndianaUniv
Larry Einhorn: The Breakthrough, The Cure, The Vision, The Legacy, The Teacher
https://medicine.iu.edu/magazine/larry-einhorn
5/ Tamoxifen for treatment of breast cancer. 1974. V. Craig Jordan, Walpole, Richardson, Harper,Ushered hormone therapy as treatment for cancer. (beyond the surgical approaches until then).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780369/
6/ Cure of diffuse large cell lymphoma with combination chemotherapy. 1975. @DeVitaDoctor and colleagues. @theNCIThis figure below, and the claim of cure made in the article, a classic, stood the test of time. @TheLancet thelancet.com/journals/lance…
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(75)91142-3/fulltext
7/ Imatinib (Gleevec) for chronic myeloid leukemia. Dramatic treatment that turned around a fatal cancer. The very essence of what targeted therapy is. 1998. Brian Druker. @nytimes8/ The first monoclonal antibody for the treatment of cancer: Rituximab. 1997. Ron Levy, David Maloney and colleagues. pnas.org/doi/10.1073/pn… @PNASNews
https://www.pnas.org/doi/10.1073/pnas.1008810107
9/ Immunomodulatory drugs: Taking the most scorned drug ever (thalidomide) & making it into an effective cancer treatment. 1998. Bart Barlogie.
Thalidomide and it’s derivatives Revlimid & Pomlyst revolutionized treatment of myeloma. @nytimes
10/ CAR-T cells. Immunotherapy using the patients’ own T cells to treat and even cure advanced cancer. 2012 Carl June. First approval 2017. @PennMedicine
https://www.lancastergeneralhealth.org/health-hub-home/2022/june/how-penn-medicine-pioneered-car-t-cell-therapy-to-treat-cancer
Just missed the list:Cladribine – cure of hairy cell leukemia
ATRA for acute promyelocytic leukemia
Join and add to the list!
What have I missed?
6 of the 10 on the list cured previously incurable systemic cancer with finite duration therapy and established an aspirational vision for all cancers. Where we need to be. The others had dramatic and sustained impact on a cancer or the field overall.They challenge us.
Great points in replies about check point inhibitors, ondansetron, allogeneic transplantation.
— Read on threadreaderapp.com/thread/1609928824866893824.html
neuropsychiatry,epileptology, pulmonology and beyond.
deemagclinic
deemag and chest clinic 