Tag Archives: carnitine and hyperammonemia
Valproate, carnitine and hyperammonemia
Therapy with valproate is associated with hyperammonemia, usually less than 2-3 times the upper limit of the reference range. It is frequent in patients on combination therapy for epilepsy. The mechanism is decreased production of mitochondrial acetyl CoA, which causes decrease in N -acetylglutamate, an activator of carbamoyl phosphate synthetase. Thus, patients with partial enzyme […]
deemagclinic
deemag and chest clinic 