Hypothyroidism manifesting as ischemic heart disease in elderly without significant coronary atherosclerosis

ECE 2013: Hypothyroidism manifesting as ischemic heart disease in elderly without significant coronary atherosclerosis
RSi CommunicationsApr 30, 20130 view
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as presented at the 15th European Congress of Endocrinology
Researchers at the Tyumen Cardiology Center, Tyumen, Russia, and Italian colleagues, designed a study to determine predictors of significant coronary atherosclerosis (SCA) absence in elderly ischemic heart disease (IHD) patients. They presented their research in a poster at ECE 2013, held in April-May of 2013 in Copenhagen.

Theirs was a retrospective study of consecutive 10,713 patients who underwent coronary angiography at the Tyumen Cardiology Centre in from 1991 to 2011, focusing on a group of 1483 patients with IHD and without SCA — 124 patients 65 years old and older (group I) and 1359 patients younger than 65 years (group II).

The researchers reported, in patients of group I the incidence of hypothyroidism was higher and incidence of myocardial infarction (MI) was lower compared with group II. Echocardiographic indices of left ventricular (LV) posterior wall thickness, aortic root, and left atrium in group I patients were higher. Left ventricular diastolic dysfunction was more frequent in patients of group I.

According to the results of multivariate analysis, LV diastolic dysfunction (odds ratio [OR] 2.64; 95% confidence interval [CI] 1.21-5.77; P=0.001), hypothyroidism (2.35; 1.45-3.81; 0.015), increased indices of LV posterior wall thickness (1.67; 1.45-3.81; 0.019), left atrium (1.31; 1.09-2.55; 0.002), aortic root (1.26; 1.11-1.55; 0.006), and the absence of prior MI (0.34; 0.15-0.79; 0.011) were independent predictors of SCA absence in elderly patients with IHD.

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