Tag Archives: Substance dependence

Evidence-Based Treatments of Addiction

Charles P. O’Brien FOCUS 2011;9:107-117.   Both pharmacotherapy and behavioural treatment are required to relieve the symptoms of addictive disorders. This paper reviews the evidence for the benefits of pharmacotherapy and discusses mechanisms where possible. Animal models of addiction have led to some medications that are effective in reducing symptoms and improving function but they […]

drug dependence

_ _ _ _ Some people who use drugs use large enough amounts often enough and long enough to become dependent. Definitions A single definition for drug dependence is elusive. Concepts that aid in defining drug dependence are tolerance and psychologic and physical dependence. Tolerance describes the need to progressively increase the drug dose to […]