Covid-19 virus has high tropism (attraction) to the liver and biliary system, BUT does not cause direct liver injury or liver failure
- Liver test abnormalities are common in severe and critical Covid-19 but are not directly due to the virus, but severity of Covid-19, part of multiple organ dysfunction and due to various drugs used in treatment
- Alcohol-associated liver disease is an independent risk factor for worse clinical outcomes in Covid-19, but not non-alcoholic fatty liver disease
- The presence of liver fat percentage 10% and above was associated with higher disease severity, independent of obesity.
- Chronic liver disease or cirrhosis does not increase risk of infection, but once infected, depending on the severe stage of cirrhosis, the Covid-19 outcomes can be worse – i.e., patients with stable liver disease who become unstable (acute decompensation) or those who develop liver failure (called ACLF) have poor outcomes (death/liver transplantation)
- Patients with liver cancer have bad outcomes with Covid-19 infection
- There is no long-Covid involvement of the liver in those with chronic liver disease who survive mild or severe Covid-19 infection
- Covid-19 vaccination prevents severe disease and also progression of pre-existing liver disease and is safe and effective in preventing death in those with underlying liver disease.
Read more here (needs University/Hospital or personal subscription):
“Investigating the correlation between COVID-19 and the progression of chronic liver disease:” tandfonline.com/doi/full/10.10…