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Gout: Integrating facts and science by Dr. Rohini Handa- Part 1

M3 India Newsdesk

Jun 19, 2018

Dr. Rohini Handa, a noted Rheumatologist from Delhi with rich experience in his field, explains in detail about the clinical presentation of gout and the interesting myths, facts, and science surrounding the disease.

In this 2 part series, Dr. Rohini Handa, a noted Rheumatologist takes us on an interesting journey of ‘Gout- the oldest type of inflammatory arthritis’, detailing on its history, associated myths, and discussing modern-day treatment on the way.

This Part 1 throws light on the clinical picture and diagnosis of Gout. Part 2 will shed light on the treatment courses.

Gout is often dubbed as the king of diseases and a disease of the kings. It is crystal arthritis characterized by hyperuricemia and deposition of monosodium urate (MSU) crystals. Aging of the population and lifestyle changes, especially the epidemic of metabolic syndrome in Indians, has made this disease ubiquitous. Despite its commonality, the disease is shrouded in myths. This write up dispels some long-held misconceptions while discussing the current concepts in light of the new knowledge that has become available.

The clinical picture

The clinical picture of a classical attack of gout is so characteristic that investigations are not needed. Contrary to popular perception, the role of serum uric acid (SUA) is more in monitoring therapy than in diagnosis.

The gold standard for diagnosis is the demonstration of MSU crystals in synovial fluid. Though MSU crystals may be picked up on ordinary light microscopy, polarized light microscopy which permits detection of birefringence characteristics is ideal. Crystal identification relies on shape and birefringence. MSU crystals may be intracellular or extracellular, are needle-shaped and exhibit strongly negative birefringence.

‘Strong’ birefringence means that crystal is bright and easily seen whereas ‘weakly’ birefringent crystal is subdued and difficult to see. ‘Positive’ and ‘negative’ birefringence refers to colors in reference to athe lignment of the red compensator. MSU crystals are yellow when parallel to the slow axis of the red compensator (negative birefringence).

A high serum uric acid in the context of a typical clinical setting substantiates the diagnosis. However, elevated SUA does not always mean gout. Clinical correlation and pattern recognition are important. Conversely, SUA may be normal during an acute attack because ACTH released in response to stress is uricosuric.

Diagnosis of Gout: Fact File for a Clinician

Gout typically causes mono/oligoarticular disease

Women account for ~5% cases of gout and 90% of affected women are postmenopausal. In premenopausal women with gout one should screen for HT, renal insufficiency or diuretic use

Since gout causes mono/oligoarthritis and is rare in premenopausal women, ordering SUA in premenopausal females with polyarthritis is not warranted in most instances

SUA may be normal during an acute attack of gout

Gout in the elderly is a unique subset: gender distinction is blurred-males and females are equally affected, attacks of gout can be polyarticular, upper limbs can be affected, tophi can come up relatively early and NSAID toxicity is common

Ultrasound and Dual Energy CT are new modalities to diagnose gout

Recommended dietary restrictions

Diet in gout is a matter of endless debate and ceaseless controversy. Most of the aphorisms are rooted in hearsay and not in science.

Purines in the diet should be restricted to <200 mg/day. However, dietary purine restriction has only a modest effect on SUA lowering.

A low purine diet is not the same as a low protein diet.

Myths and Facts associated with Gout

Top Myths

Irrefutable Facts

Hyperuricemia is Gout

Hyperuricemia is one of the risk factors for Gout. Not all hyperuricemics develop gout.

Shoot everything that moves. Use ULT in all patients with hyperuricemia

Asymptomatic hyperuricemia usually does not need treatment. Detection of asymptomatic hyperuricemia mandates search for co-morbidities like hyperlipidemia, diabetes etc.

Gout means goodbye to proteins

Purines and proteins are different. Low-fat dairy products reduce the risk of gout. Moderation of portion size more important than total restriction.

Treat the episode and you are done

Treatment is lifelong. Doses of drugs may reduce but duration is indefinite.

Allopurinol is the drug to treat acute Gout

Allopurinol is a urate-lowering agent. Institute Urate Lowering Treatments only after acute attack controlled.

Protein intake needs to be restricted only in those consuming very high amounts of proteins which is not common in Indians.

Items rich in purine which should be avoided include red meat, liver, kidney, sardines, shellfish and some other varieties of seafood. The total amount of purine in the diet is more important than the item consumed. Spinach, pulses (lentils), peas, mushrooms, cauliflower, soya beans etc are rich in purines but cause a much lower rise in SUA than meat.

Moderate intake of purine-rich vegetables is not a problem.

There is no rationale behind totally stopping tomatoes, spinach, pulses, peas, mushrooms etc. in all patients.

Blanket dietary restrictions are difficult to enforce. Moderation rather than total abstinence is key to ensuring adherence. Skimmed milk and curd (yogurt) and low-fat dairy are beneficial.

Patients with gout should be encouraged to abstain from alcohol. Amongst alcoholic drinks, beer is the biggest offender while wine (especially red wine) is the least with whiskey figuring in between wine and beer.

Part 2 of this series discusses the treatment for Gout. Read it here.

Disclaimer- The views and opinions expressed in this article are those of the author’s and do not necessarily reflect the official policy or position of M3 India.

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