Severity of COVID19 shows an extraordinary correlation with increasing age. In an animal study, the researchers generated a mouse model for severe COVID19 1/
The study shows that the age-dependent disease severity is caused by the disruption of a timely and well-coordinated innate and adaptive immune response due to impaired interferon (IFN) immunity. 2/
Aggravated disease in aged mice reflected a reduced IFN-γ response & excessive virus replication. Similarly, adult IFN-γ receptor-deficient mice phenocopied the age-related disease severity,& supplementation of IFN-γ reversed the increased disease susceptibility of aged mice 3/
Further, they show that therapeutic treatment with IFN-λ in adults and a combinatorial treatment with IFN-γ and IFN-λ in aged Ifnar1-/- mice was highly efficient in protecting against severe disease. 4/
So, this study provides an explanation for the age-dependent disease severity and clarify the nonredundant antiviral functions of type I, II, and III IFNs during SARS2 infection in an age-dependent manner. 5/
Further, the data suggest that highly vulnerable individuals could benefit from immunotherapy combining IFN-γ and IFN-λ. 6/
Impaired immune response drives age-dependent severity of COVID-19 – PubMedSeverity of COVID-19 shows an extraordinary correlation with increasing age. We generated a mouse model for severe COVID-19 and show that the age-dependent disease severity is caused by the disruption…https://pubmed.ncbi.nlm.nih.gov/36129445/
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